Rapidly absorbed liquid compositions

Abstract

The present invention provides a method which provides for a faster absorption of pharmaceutically acceptable amines. The method provides a pharmaceutically acceptable amine in combination with a non-steroidal anti-inflammatory drug in a liquid form. A preferred embodiment employs pseudoephedrine and ibuprofen.

We claim:  
     
         1 . A method for providing enhanced absorption of a pharmaceutically acceptable amine into the blood of a human comprising providing a pharmacologically effective dosage of a pharmaceutically acceptable amine and an effective amount of a nonsteroidal anti-inflammatory acidic drug in a stable liquid form.  
     
     
         2 . The method of  claim 1  wherein the enhanced absorption is indicated by AUC    1 H  (early drug exposure) that is at least about 10% higher than the early drug exposure of the same amine from a single-ingredient liquid.  
     
     
         3 . The method of  claim 1  wherein the enhanced absorption is indicated by AUC    2 H  (early drug exposure) that is at least about 10% higher than the early drug exposure of the same amine from a single-ingredient liquid.  
     
     
         4 . The method of  claim 1  wherein the enhanced absorption is indicated by a C MAX  (maximum or peak concentration) that is at least about 10% greater than the C MAX  of the same amine from a single-ingredient liquid.  
     
     
         5 . The method of  claim 1  wherein the stable liquid form is a suspension.  
     
     
         6 . The method of  claim 1  wherein the amine is pseudoephedrine.  
     
     
         7 . The method of  claim 1  wherein the nonsteroidal anti-inflammatory drug is ibuprofen.  
     
     
         8 . The method of  claim 6  wherein the pseudoephedrine is provided in a range from about 15 mg to about 60 mg per dosage unit.  
     
     
         9 . The method of  claim 6  wherein the pseudoephedrine is provided in a range from about 15 mg to about 45 mg per dosage unit.  
     
     
         10 . The method of  claim 7  wherein the ibuprofen is provided in an amount of from about 40 mg to about 800 mg per dosage unit.  
     
     
         11 . The method of  claim 7  wherein the ibuprofen is provided in an amount of from about 40 mg to about 300 mg per dosage unit.  
     
     
         12 . The method of  claim 1  wherein the amine is pseudoephedrine at about 15 milligrams and the nonsteroidal anti-inflammatory is ibuprofen provided at a level at about 100 milligrams per 6 mL.  
     
     
         13 . The method of  claim 1  wherein the human is a child.  
     
     
         14 . A composition comprising a pharmacologically effective amount of a pharmaceutically acceptable amine and a pharmacologically effective amount of a nonsteroidal anti-inflammatory drug, said amine and nonsteroidal anti-inflammatory drug are provided in a stable liquid form.  
     
     
         15 . The composition of  claim 14  wherein the stable liquid form is a suspension.  
     
     
         16 . The composition of  claim 14  wherein the nonsteroidal anti-inflammatory drug is ibuprofen and the pharmaceutically acceptable amine is pseudoephedrine.  
     
     
         17 . The composition of  claim 16  wherein the ibuprofen is provided at dosage of about 100 milligrams and the pseudoephedrine is provided at a dosage of about 15 milligrams per 6 mL.