N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl}phenyl)acetamide and compositions and, methods related thereto

Abstract

N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide, and use of the same as a sedative-hypnotic, anxiolytic, anticonvulsant, and skeletal muscle relaxant agent. Compositions containing N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide, as well as pharmaceutically acceptable salts thereof, are also disclosed.

1 . N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and pharmaceutically acceptable salts thereof.  
     
     
         2 . A composition comprising N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.  
     
     
         3 . The composition of  claim 2 , wherein the composition is formulated for oral administration.  
     
     
         4 . The composition of  claim 3  wherein the composition is in the form of a pill, capsule or tablet.  
     
     
         5 . The composition of  claim 2  in dosage unit form comprising from 0.1 to 250 mg of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide,  
     
     
         6 . A method for treating insomnia in a patient in need thereof, comprising administering to the patient an effective amount of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide or a pharmaceutically acceptable salt thereof.  
     
     
         7 . A method for inducing sleep in a patient in need thereof, comprising administering to the patient an effective amount of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide or a pharmaceutically acceptable salt thereof.  
     
     
         8 . A method for inducing sedation or hypnosis in a patient in need thereof, comprising administering to the patient an effective amount of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl} phenyl)acetamide or a pharmaceutically acceptable salt thereof.  
     
     
         9 . A method for inducing skeletal muscle relaxation in a patient in need thereof, comprising administering to the patient an effective amount of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide or a pharmaceutically acceptable salt thereof.