US2002147359A1PendingUtilityA1
Intermediate compound for preparing guanidine and amidine derivatives
Priority: May 30, 1998Filed: Feb 25, 2002Published: Oct 10, 2002
Est. expiryMay 30, 2018(expired)· nominal 20-yr term from priority
C07D 295/215C07D 239/12A61P 43/00C07C 2601/14C07D 233/44
48
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Abstract
The invention relates to new compounds of general formula I or the pharmaceutically acceptable salts thereof, wherein X=N−R 3 or CH−R 4 , Y=CH 2 or (CH 2 ) 2 , Z=O or H 2 ; and R 1 , R 2 , R 3 , R 4 and Ar have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin) antagonists.
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