Inventor · disambiguated record
Lyle W. Spruce
Also filed as: SPRUCE LYLE · SPRUCE LYLE W
36 granted patents·6 pending applications·1,118 citations·filing 1987–2006
98Inventor score
Files withCORTECH INC27ORTHO MCNEIL PHARM INC4INCYTE SAN DIEGO2OKLAHOMA COLL AGRI MECH2PFAHL MAGNUS2
Top patents by PatentIndex Score
42 records- 0197US5861380ASerine protease inhibitors-keto and di-keto containing ring systemsCORTECH INC·Filed 1996·Granted Jan 19, 1999·144 cites·124 claims
- 0294US6159938ASerine protease inhibitors comprising α-keto heterocyclesCORTECH INC·Filed 1997·Granted Dec 12, 2000·146 cites·77 claims
- 0394US6004933ACysteine protease inhibitorsCORTECH INC·Filed 1998·Granted Dec 21, 1999·159 cites·146 claims
- 0492US5618792ASubstituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastaseCORTECH INC·Filed 1994·Granted Apr 8, 1997·63 cites·12 claims
- 0590US6765013B2Thiazolidinedione derivatives for the treatment of diabetes and other diseasesINCYTE SAN DIEGO·Filed 2002·Granted Jul 20, 2004·37 cites·32 claims
- 0689US6515003B1Heterocyclic derivatives for the treatment of diabetes and other diseasesMAXIA PHARMACEUTICALS INC·Filed 2000·Granted Feb 4, 2003·42 cites·23 claims
- 0785US5869455ASerine protease inhibitors-N-substituted derivativesCORTECH INC·Filed 1996·Granted Feb 9, 1999·40 cites·19 claims
- 0885US4977276AHeteroarotinoids as anticancer agentsOKLAHOMA COLL AGRI MECH·Filed 1989·Granted Dec 11, 1990·22 cites·9 claims
- 0983US6075120ABradykinin antagonistCORTECH INC·Filed 1995·Granted Jun 13, 2000·43 cites·11 claims
- 1082US5807829ASerine protease inhibitor--tripeptoid analogsCORTECH INC·Filed 1996·Granted Sep 15, 1998·34 cites·17 claims
- 1182US5801148ASerine protease inhibitors-proline analogsCORTECH INC·Filed 1996·Granted Sep 1, 1998·34 cites·21 claims
- 1280US7226940B2Substituted heterocycles for the treatment of diabetes and other diseasesORTHO MCNEIL PHARM INC·Filed 2005·Granted Jun 5, 2007·3 cites·20 claims
- 1380US6001814ASerine protease inhibitorsCORTECH INC·Filed 1998·Granted Dec 14, 1999·25 cites·23 claims
- 1479US6608175B2Serine protease inhibitorsCORTECH INC·Filed 2001·Granted Aug 19, 2003·4 cites·14 claims
- 1579US5874585ASubstituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastaseCORTECH INC·Filed 1996·Granted Feb 23, 1999·28 cites·7 claims
- 1678US7153875B2Heterocyclic derivatives for the treatment of cancer and other proliferative diseasesINCYTE SAN DIEGO·Filed 2002·Granted Dec 26, 2006·13 cites·9 claims
- 1778US4833254AHeteroarotinoids as anticancer agentsOKLAHOMA COLL AGRI MECH·Filed 1987·Granted May 23, 1989·14 cites·9 claims
- 1877US7071218B2N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders; cancer, and other diseasesORTHO MCNEIL PHARM INC·Filed 2002·Granted Jul 4, 2006·10 cites·45 claims
- 1975US6015791ASerine protease inhibitors-cycloheptane derivativesCORTECH INC·Filed 1997·Granted Jan 18, 2000·26 cites·32 claims
- 2075US6001813AVal-pro containing α-keto oxadiazoles as serine protease inhibitorsCORTECH INC·Filed 1998·Granted Dec 14, 1999·25 cites·13 claims
- 2174US6974826B2Imidazolidinedione derivatives for the treatment of diabetes and other diseasesORTHO MCNEIL PHARM INC·Filed 2004·Granted Dec 13, 2005·5 cites·32 claims
- 2274US5863899ABradykinin antagonistsCORTECH INC·Filed 1994·Granted Jan 26, 1999·30 cites·12 claims
- 2371US7196108B2Bicyclic heterocycles for the treatment of diabetes and other diseasesORTHO MCNEIL PHARM INC·Filed 2003·Granted Mar 27, 2007·7 cites·61 claims
- 2471US6656911B2Serine protease inhibitorsCORTECH INC·Filed 2002·Granted Dec 2, 2003·3 cites·71 claims
- 2571US6255453B1Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitorsCORTECH INC·Filed 1999·Granted Jul 3, 2001·22 cites·1 claims
- 2671US6037325ASubstituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastaseCORTECH INC·Filed 1998·Granted Mar 14, 2000·18 cites·12 claims
- 2770US6548638B2Peptoid and nonpeptoid containing α-keto oxadiazoles as serine protease inhibitorsCORTECH INC·Filed 2001·Granted Apr 15, 2003·3 cites·1 claims
- 2870US5663416AOxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastaseCORTECH INC·Filed 1995·Granted Sep 2, 1997·12 cites·23 claims
- 2969US6150334ASerine protease inhibitors-tripeptoid analogsCORTECH INC·Filed 1997·Granted Nov 21, 2000·13 cites·29 claims
- 3069US6100238AIndole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitorsCORTECH INC·Filed 1998·Granted Aug 8, 2000·12 cites·42 claims
- 3167US5891852ASerine protease inhibitors-cycloheptane derivativesCORTECH INC·Filed 1996·Granted Apr 6, 1999·14 cites·25 claims
- 3267US5843900ABradykinin antagonistsCORTECH INC·Filed 1995·Granted Dec 1, 1998·31 cites·21 claims
- 3365US6001811ASerine protease inhibitors--N-substituted derivativesCORTECH INC·Filed 1997·Granted Dec 14, 1999·16 cites·21 claims
- 3462US6656910B2Serine protease inhibitorsCORTECH INC·Filed 2001·Granted Dec 2, 2003·2 cites·92 claims
- 3557US5214191AOxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastaseCORTECH INC·Filed 1990·Granted May 25, 1993·12 cites·15 claims
- 3656US5998379ASerine protease inhibitors-proline analogsCORTECH INC·Filed 1997·Granted Dec 7, 1999·6 cites·13 claims
- 3756US2002119985A1Serine protease inhibitorsFiled 2001·Application pending·0 cites
- 3851US2003176642A1Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitorsFiled 2003·Application pending·0 cites
- 3950US2006160796A1N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders; cancer, and other diseasesPFAHL MAGNUS·Filed 2006·Application pending·0 cites
- 4047US2005209286A1RXR activating moleculesPFAHL MAGNUS·Filed 2005·Application pending·0 cites
- 4138US2004097566A12-Substituted thiazolidinone and oxazolidinone derivatives for the inhibition of phosphatases and the treatment of cancerFiled 2002·Application pending·0 cites
- 4238US2005014767A1Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseasesFiled 2004·Application pending·0 cites
Identity basis: PatentsView inventor disambiguation (2025Q4-odp release). How scoring works →