Inventor · disambiguated record
Chien-Hsing Chang
Also filed as: CHANG CHIEN H · CHANG CHIEN-HSING · CHANG CHIEN-HSING K · CHANG CHIEN-HSING KEN
157 granted patents·63 pending applications·3,523 citations·filing 1992–2025
99Inventor score
Files withIMMUNOMEDICS INC94IBC PHARMACEUTICALS INC63CHANG CHIEN-HSING25E INK HOLDINGS INC10GOLDENBERG DAVID M10
Top patents by PatentIndex Score
220 records- 0199US8349332B2Multiple signaling pathways induced by hexavalent, monospecific and bispecific antibodies for enhanced toxicity to B-cell lymphomas and other diseasesIBC PHARMACEUTICALS INC·Filed 2011·Granted Jan 8, 2013·58 cites·12 claims
- 0299US8034352B2Tetrameric cytokines with improved biological activityIBC PHARMACEUTICALS INC·Filed 2010·Granted Oct 11, 2011·61 cites·6 claims
- 0399US7906121B2Methods and compositions for generating bioactive assemblies of increased complexity and usesIBC PHARMACEUTICALS INC·Filed 2009·Granted Mar 15, 2011·125 cites·25 claims
- 0499US7906118B2Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technologyIBC PHARMACEUTICALS INC·Filed 2009·Granted Mar 15, 2011·90 cites·17 claims
- 0599US7901680B2Dock-and-lock (DNL) vaccines for cancer therapyIBC PHARMACEUTICALS INC·Filed 2009·Granted Mar 8, 2011·92 cites·19 claims
- 0699US7666400B2PEGylation by the dock and lock (DNL) techniqueIBC PHARMACEUTICALS INC·Filed 2007·Granted Feb 23, 2010·158 cites·21 claims
- 0799US7550143B2Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and usesIBC PHARMACEUTICALS INC·Filed 2006·Granted Jun 23, 2009·177 cites·21 claims
- 0899US7534866B2Methods and compositions for generating bioactive assemblies of increased complexity and usesIBC PHARMACEUTICALS INC·Filed 2006·Granted May 19, 2009·287 cites·18 claims
- 0999US7527787B2Multivalent immunoglobulin-based bioactive assembliesIBC PHARMACEUTICALS INC·Filed 2006·Granted May 5, 2009·293 cites·23 claims
- 1099US7521056B2Stably tethered structures of defined compositions with multiple functions or binding specificitiesIBC PHARMACEUTICALS INC·Filed 2006·Granted Apr 21, 2009·297 cites·28 claims
- 1198US9382329B2Disease therapy by inducing immune response to Trop-2 expressing cellsIBC PHARMACEUTICALS INC·Filed 2015·Granted Jul 5, 2016·23 cites·15 claims
- 1298US9315567B2T-cell redirecting bispecific antibodies for treatment of diseaseIBC PHARMACEUTICALS INC·Filed 2013·Granted Apr 19, 2016·47 cites·10 claims
- 1398US9187561B2Humanized anti-HLA-DR antibodiesIMMUNOMEDICS INC·Filed 2014·Granted Nov 17, 2015·35 cites·21 claims
- 1498US8992917B2Humanized L243 antibodiesIMMUNOMEDICS INC·Filed 2013·Granted Mar 31, 2015·37 cites·23 claims
- 1598US8597659B2Tetrameric cytokines with improved biological activityCHANG CHIEN-HSING·Filed 2011·Granted Dec 3, 2013·50 cites·12 claims
- 1698US8562988B2Strategies for improved cancer vaccinesCHANG CHIEN-HSING·Filed 2010·Granted Oct 22, 2013·44 cites·16 claims
- 1798US8551480B2Compositions and methods of use of immunotoxins comprising ranpirnase (Rap) show potent cytotoxic activityCHANG CHIEN-HSING·Filed 2010·Granted Oct 8, 2013·48 cites·3 claims
- 1898US8475794B2Combination therapy with anti-CD74 antibodies provides enhanced toxicity to malignancies, Autoimmune disease and other diseasesCHANG CHIEN-HSING·Filed 2011·Granted Jul 2, 2013·44 cites·7 claims
- 1998US8282934B2Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technologyCHANG CHIEN-HSING·Filed 2011·Granted Oct 9, 2012·49 cites·17 claims
- 2098US8277817B2PEGylation by the dock and lock (DNL) techniqueCHANG CHIEN-HSING·Filed 2011·Granted Oct 2, 2012·44 cites·11 claims
- 2198US8246960B2Methods and compositions for generating bioactive assemblies of increased complexity and usesCHANG CHIEN-HSING·Filed 2011·Granted Aug 21, 2012·55 cites·21 claims
- 2298US8211440B2Multivalent immunoglobulin-based bioactive assembliesCHANG CHIEN-HSING·Filed 2010·Granted Jul 3, 2012·57 cites·25 claims
- 2398US8163291B2Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and usesCHANG CHIEN-HSING·Filed 2009·Granted Apr 24, 2012·52 cites·28 claims
- 2498US8003111B2Dimeric alpha interferon pegylated site-specifically shows enhanced and prolonged efficacy in vivoIBC PHARMACEUTICALS INC·Filed 2010·Granted Aug 23, 2011·71 cites·10 claims
- 2598US7981398B2PEGylation by the dock and lock (DNL) techniqueIBC PHARMACEUTICALS INC·Filed 2009·Granted Jul 19, 2011·58 cites·25 claims
- 2698US7871622B2Stably tethered structures of defined compositions with multiple functions or binding specificitiesIBC PHARMACEUTICALS INC·Filed 2009·Granted Jan 18, 2011·74 cites·14 claims
- 2798US7858070B2Multivalent immunoglobulin-based bioactive assembliesIBC PHARMACEUTICALS INC·Filed 2009·Granted Dec 28, 2010·71 cites·12 claims
- 2897US9238084B2Anti-mucin antibodies for early detection and treatment of pancreatic cancerIMMUNOMEDICS INC·Filed 2015·Granted Jan 19, 2016·36 cites·22 claims
- 2997US9139649B2Humanized anti-CD22 antibodyIMMUNOMEDICS INC·Filed 2015·Granted Sep 22, 2015·13 cites·26 claims
- 3097US8722047B2Humanized anti-HLA-DR antibodiesGOLDENBERG DAVID M·Filed 2010·Granted May 13, 2014·33 cites·19 claims
- 3197US8613903B2Humanized L243 antibodiesGOLDENBERG DAVID M·Filed 2009·Granted Dec 24, 2013·35 cites·20 claims
- 3297US8491914B2Dock-and-lock (DNL) complexes for delivery of interference RNACHANG CHIEN-HSING·Filed 2010·Granted Jul 23, 2013·46 cites·2 claims
- 3397US8481041B2Dock-and-lock (DNL) constructs for human immunodeficiency virus (HIV) therapyCHANG CHIEN-HSING·Filed 2011·Granted Jul 9, 2013·45 cites·11 claims
- 3497US8435540B2Dimeric alpha interferon PEGylated site-specifically shows enhanced and prolonged efficacy in VIVOCHANG CHIEN-HSING·Filed 2012·Granted May 7, 2013·47 cites·9 claims
- 3597US8435539B2Delivery system for cytotoxic drugs by bispecific antibody pretargetingMCBRIDE WILLIAM J·Filed 2010·Granted May 7, 2013·34 cites·10 claims
- 3697US8333971B2Methods and compositions for treatment of human immunodeficiency virus infection with conjugated antibodies or antibody fragmentsGOLDENBERG DAVID M·Filed 2007·Granted Dec 18, 2012·29 cites·20 claims
- 3797US8287865B2Class I anti-CEA antibodies and uses thereofHANSEN HANS J·Filed 2010·Granted Oct 16, 2012·37 cites·66 claims
- 3897US8158129B2Dimeric alpha interferon PEGylated site-specifically shows enhanced and prolonged efficacy in vivoCHANG CHIEN-HSING·Filed 2011·Granted Apr 17, 2012·49 cites·10 claims
- 3996US10669338B2Anti-PD-1 checkpoint inhibitor antibodies that block binding of PD-L1 to PD-1IMMUNOMEDICS INC·Filed 2017·Granted Jun 2, 2020·11 cites·28 claims
- 4096US9670286B2Disease therapy by inducing immune response to Trop-2 expressing cellsIBC PHARMACEUTICALS INC·Filed 2016·Granted Jun 6, 2017·9 cites·14 claims
- 4196US9518115B2Humanized anti-CD22 antibodyIMMUNOMEDICS INC·Filed 2015·Granted Dec 13, 2016·9 cites·25 claims
- 4296US9475883B2Therapeutic use of anti-CD22 antibodies for inducing trogocytosisIMMUNOMEDICS INC·Filed 2015·Granted Oct 25, 2016·10 cites·13 claims
- 4396US7537930B2Mammalian cell lines for increasing longevity and protein yield from a cell cultureIMMUNOMEDICS INC·Filed 2006·Granted May 26, 2009·30 cites·12 claims
- 4495US10111954B2Combination therapy for inducing immune response to diseaseIBC PHARMACEUTICALS INC·Filed 2016·Granted Oct 30, 2018·8 cites·13 claims
- 4595US9944703B2Humanized anti-CD22 antibodyIMMUNOMEDICS INC·Filed 2017·Granted Apr 17, 2018·7 cites·6 claims
- 4695US9701748B2Humanized anti-CD22 antibodyIMMUNOMEDICS INC·Filed 2016·Granted Jul 11, 2017·7 cites·13 claims
- 4795US9682143B2Combination therapy for inducing immune response to diseaseIBC PHARMACEUTICALS INC·Filed 2013·Granted Jun 20, 2017·18 cites·13 claims
- 4895US9352036B2Delivery system for cytotoxic drugs by bispecific antibody pretargetingIMMUNOMEDICS INC·Filed 2013·Granted May 31, 2016·12 cites·16 claims
- 4995US8865176B2Methods and compositions for generating bioactive assemblies of increased complexity and usesCHANG CHIEN-HSING·Filed 2012·Granted Oct 21, 2014·9 cites·4 claims
- 5095US7785880B2Mammalian cell lines for increasing longevity and protein yield from cell cultureIMMUNOMEDICS INC·Filed 2009·Granted Aug 31, 2010·21 cites·7 claims
Showing the top 50 of 220 patent records by PatentIndex Score.
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