Inventor · disambiguated record
Timothy A. Springer
Also filed as: SPRINGER TIMOTHY · SPRINGER TIMOTHY A · SPRINGER TIMOTHY ALAN
46 granted patents·11 pending applications·1,209 citations·filing 1981–2025
98Inventor score
Files withDANA FARBER CANCER INST INC19BLOOD RES CENTER15CHILDRENS MEDICAL CT CORP6CHILDRENS MEDICAL CENTER2IMMUNE DISEASE INST INC2
Top patents by PatentIndex Score
57 records- 0194US5460945ADevice and method for analysis of blood components and identifying inhibitors and promoters of the inflammatory responseBLOOD RES CENTER·Filed 1992·Granted Oct 24, 1995·209 cites·101 claims
- 0293US5284931AIntercellular adhesion molecules, and their binding ligandsDANA FARBER CANCER INST INC·Filed 1990·Granted Feb 8, 1994·95 cites·11 claims
- 0391US10273283B2Modified integrin polypeptides, modified integrin polypeptide dimers, and uses thereofCHILDRENS MEDICAL CT CORP·Filed 2017·Granted Apr 30, 2019·7 cites·16 claims
- 0490US7241869B2Modified polypeptides stabilized in a desired conformation and methods for producing sameBLOOD RES CENTER·Filed 2005·Granted Jul 10, 2007·12 cites·10 claims
- 0590US4956281ADNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3BIOGEN INC·Filed 1987·Granted Sep 11, 1990·108 cites·10 claims
- 0688US6683158B2Alpha-subunit of the Mac-1 leukocyte adhesion receptorDANA FARBER CANCER INST INC·Filed 2002·Granted Jan 27, 2004·26 cites·4 claims
- 0788US5514555AAssays and therapeutic methods based on lymphocyte chemoattractantsBLOOD RES CENTER·Filed 1993·Granted May 7, 1996·139 cites·23 claims
- 0887US5288854AFunctional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1BLOOD RES CENTER·Filed 1990·Granted Feb 22, 1994·79 cites·5 claims
- 0985US5475091AR6-5-D6, an antibody which binds intercellular adhesion molecule-1DANA FARBER CANCER INST INC·Filed 1994·Granted Dec 12, 1995·45 cites·2 claims
- 1082US8021668B2Integrin alpha L I domain mutants with increased binding affinityIMMUNE DISEASE INST INC·Filed 2006·Granted Sep 20, 2011·8 cites·6 claims
- 1182US7160541B2Modified polypeptides stabilized in a desired conformation and methods for producing sameBLOOD RES CENTER·Filed 2001·Granted Jan 9, 2007·11 cites·13 claims
- 1282US2024117006A1Modified integrin polypeptides, modified integrin polypeptide dimers, and uses thereofCHILDRENS MEDICAL CT CORP·Filed 2023·Application pending·0 cites
- 1381US7674604B2Modified polypeptides stabilized in a desired conformation and methods for producing sameBLOOD RES CENTER·Filed 2005·Granted Mar 9, 2010·3 cites·7 claims
- 1481US5071964AProtein micellesDANA FARBER CANCER INST INC·Filed 1990·Granted Dec 10, 1991·53 cites·6 claims
- 1580US11104713B2Modified integrin polypeptides, modified integrin polypeptide dimers, and uses thereofCHILDRENS MEDICAL CT CORP·Filed 2019·Granted Aug 31, 2021·1 cites·20 claims
- 1679US4427653AMethod of making monoclonal antibodiesHARVARD COLLEGE·Filed 1981·Granted Jan 24, 1984·36 cites·1 claims
- 1776US7879577B2Modified polypeptides stabilized in a desired conformation and methods for producing sameBLOOD RES CENTER·Filed 2009·Granted Feb 1, 2011·1 cites·5 claims
- 1876US5891841AMethods of using intercellular adhesion molecule-3 (ICAM-3), antibodies thereto, and soluble fragments thereofBLOOD RES CENTER·Filed 1995·Granted Apr 6, 1999·25 cites·28 claims
- 1976US5877295AAntibodies which bind a subpopulation of Mac-1 (CD11b/CD18) molecules which mediate neutrophil adhesion to ICAM-1 and fibrinogenBLOOD RES CENTER·Filed 1995·Granted Mar 2, 1999·29 cites·5 claims
- 2076US2022064261A1Modified integrin polypeptides, modified integrin polypeptide dimers, and uses thereofCHILDRENS MEDICAL CT CORP·Filed 2021·Application pending·0 cites
- 2175US8241627B2Modified polypeptides stabilized in a desired conformation and methods for producing sameSPRINGER TIMOTHY A·Filed 2011·Granted Aug 14, 2012·2 cites·8 claims
- 2275US2025206802A1Modified integrin polypeptides, modified integrin polypeptide dimers, and uses thereofCHILDRENS MEDICAL CT CORP·Filed 2025·Application pending·0 cites
- 2371US6030947AMethods of treating p150,95-mediated inflammation and ICAM-1-mediated viral infectionDANA FARBER CANCER INST INC·Filed 1997·Granted Feb 29, 2000·16 cites·11 claims
- 2471US5612216ANucleotide sequence encoding intercellular adhesion molecule-1 and fragments thereofDANA FARBER CANCER INST INC·Filed 1994·Granted Mar 18, 1997·23 cites·10 claims
- 2569US7927591B2Conformation specific antibodiesCBR INST FOR BIOMEDICAL RES INC·Filed 2005·Granted Apr 19, 2011·2 cites·14 claims
- 2667US5831036ASoluble fragments of human intercellular adhesion molecule-1DANA FARBER CANCER INST INC·Filed 1993·Granted Nov 3, 1998·22 cites·4 claims
- 2767US5629162AMethod of identifying agents which modulate ICAM-3 binding to LFA-1BLOOD RES CENTER·Filed 1995·Granted May 13, 1997·26 cites·17 claims
- 2867US5599676AMethod for isolating a novel receptor for α4 integrinsBLOOD RES CENTER·Filed 1994·Granted Feb 4, 1997·29 cites·10 claims
- 2965US8877893B2Stabilized low affinity conformation of integrins for drug discoverySPRINGER TIMOTHY A·Filed 2009·Granted Nov 4, 2014·2 cites·3 claims
- 3062US5395929AIsolated nucleic acid encoding the alpha subunit of the human leukocyte adhesion receptorDANA FARBER CANCER INST INC·Filed 1993·Granted Mar 7, 1995·20 cites·6 claims
- 3161US5739032ACloning LFA-1DANA FARBER CANCER INST INC·Filed 1994·Granted Apr 14, 1998·12 cites·11 claims
- 3261US5565550AAntibodies to ICAM-2, and fragments thereofDANA FARBER CANCER INST INC·Filed 1994·Granted Oct 15, 1996·21 cites·4 claims
- 3361US5489533AIsolated nucleic acid molecules encoding ICAM-2DANA FARBER CANCER INST INC·Filed 1995·Granted Feb 6, 1996·23 cites·4 claims
- 3459US6358510B1ICAM-1 derivatives with altered ability to bind LFA-1DANA FARBER CANCER INST INC·Filed 1995·Granted Mar 19, 2002·15 cites·4 claims
- 3559US5190859APurification of LFA-3DANA FARBER CANCER INST INC·Filed 1989·Granted Mar 2, 1993·18 cites·12 claims
- 3658US5849896Aα-subunit of the Mac-1 leukocyte adhesion receptorDANA FARBER CANCER INST INC·Filed 1995·Granted Dec 15, 1998·11 cites·4 claims
- 3758US5686265ALeukocyte adhesion receptorsDANA FARBER CANCER INST INC·Filed 1994·Granted Nov 11, 1997·11 cites·11 claims
- 3857US7968284B2Modified polypeptides stabilized in a desired conformation and methods for producing sameBLOOD RES CENTER·Filed 2010·Granted Jun 28, 2011·0 cites·8 claims
- 3956US2015044779A1Stabilized low affinity conformation of integrins for drug discoveryCHILDRENS MEDICAL CENTER·Filed 2014·Application pending·0 cites
- 4055US5948758AMethods for treating various disease states by reducing adhesion of leukocytes of target cellsDANA FARBER CANCER INST INC·Filed 1997·Granted Sep 7, 1999·10 cites·9 claims
- 4154US11136383B2Methods and compositions for modulaton of transforming growth factor beta-regulated functionsCHILDRENS MEDICAL CT CORP·Filed 2017·Granted Oct 5, 2021·0 cites·10 claims
- 4254US2020024339A1Compositions and methods for modulating cell signalingSCHOLAR ROCK INC·Filed 2019·Application pending·0 cites
- 4354US2009035321A1Intercellular adhesion molecules and their binding ligandsBOEHRINGER INGELHEIM PHARMA·Filed 2006·Application pending·0 cites
- 4453US6797270B1Functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapyBLOOD RES CENTER·Filed 1995·Granted Sep 28, 2004·12 cites·4 claims
- 4553US2016084825A1Stabilized low affinity conformation of integrins for drug discoveryCHILDRENS MEDICAL CENTER·Filed 2015·Application pending·0 cites
- 4652US6511664B1Intercellular adhesion molecule—2 and its binding ligandsDANA FARBER CANCER INST INC·Filed 1996·Granted Jan 28, 2003·12 cites·4 claims
- 4752US2015284455A1Compositions and methods for modulating cell signalingSCHOLAR ROCK INC·Filed 2013·Application pending·0 cites
- 4851US6436403B1Pharmaceutical composition of the intercellular adhesion molecule ICAM-1 for use in anti-viral prophylactic therapyBLOOD RES CENTER·Filed 1995·Granted Aug 20, 2002·11 cites·2 claims
- 4951US5512660APurified ICAM-2 and fragment thereofDANA FARBER CANCER INST INC·Filed 1994·Granted Apr 30, 1996·14 cites·2 claims
- 5051US2022348609A1Computational design of alpha(v) beta (6) integrin binding proteinsUNIV WASHINGTON·Filed 2020·Application pending·0 cites
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